Disruption of Glomerular Basement Membrane Charge through Podocyte-Specific Mutation of Agrin Does Not Alter Glomerular Permselectivity
نویسندگان
چکیده
منابع مشابه
Bovine Glomerular Basement Membrane
The collagenous domain of bovine glomerular basement membrane was excised in soluble form by limited pepsin digestion and characterized. The domain amounts to approximately 25% of the whole membrane by weight. The constituent polypeptides were studied using several electrophoresis systems and amino acid analysis. The electrophoresis systems used were a combination of agarose and polyacrylamide...
متن کاملGlomerular Basement Membrane
The noncollagenous domain hexamer of collagen IV from bovine glomerular basement membrane was further investigated to determine the types of collagen chain from which subunits M2*b and M3 are derived. M2*b was shown to be a shorter form, containing 9 fewer residues, of M2*a which was previously established as the noncollagenous domain of a third chain, a3, of collagen IV (Saus, J., Wieslander, ...
متن کاملAnti-glomerular basement membrane antibodies.
Basement membranes form an anatomic barrier that contains connective tissue. They are composed of type IV collagen, laminin and proteoglycans. Anti-basement membrane antibodies bind to the non-collagen site of the α3 chain of type IV collagen. A group of renal diseases, pulmonary diseases and perhaps others affecting different organs have long been associated with the presence of antibodies dir...
متن کاملThe glomerular basement membrane charge-selectivity barrier: an oversimplified concept?
The precise nature and role of a charge-selectivity barrier, existing at the level of the glomerular capillary wall has been the subject of continuing controversy since it was first postulated over 30 years ago. Recent studies suggest that some earlier observations may have been overinterpreted and that the conclusions reached should be re-examined. The concept of a charge-selectivity barrier a...
متن کاملAnti-Glomerular Basement Membrane Disease.
Anti-glomerular basement membrane (anti-GBM) disease is a rare small vessel vasculitis that affects the capillary beds of the kidneys and lungs. It is an archetypic autoimmune disease, caused by the development of directly pathogenic autoantibodies targeting a well characterized autoantigen expressed in the basement membranes of these organs, although the inciting events that induce the autoimm...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2007
ISSN: 0002-9440
DOI: 10.2353/ajpath.2007.061116