Dissecting Alzheimer disease in Down syndrome using mouse models
نویسندگان
چکیده
منابع مشابه
Dissecting Alzheimer disease in Down syndrome using mouse models
Down syndrome (DS) is a common genetic condition caused by the presence of three copies of chromosome 21 (trisomy 21). This greatly increases the risk of Alzheimer disease (AD), but although virtually all people with DS have AD neuropathology by 40 years of age, not all develop dementia. To dissect the genetic contribution of trisomy 21 to DS phenotypes including those relevant to AD, a range o...
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Down syndrome (DS) is the most common genetically driven intellectual disability. Neuro pathological evidence of an associa‐ tion between Alzheimer disease (AD) and DS was published 11 years before trisomy 21 was described as the cause of DS.1 AD‐type pathology is almost universal in patients with DS in their 40s, although the develop ment of clinically detectable cognitive decline typically la...
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People with Down syndrome (DS) are at high risk for developing Alzheimer disease (AD) with age. Typically, by age 40 years, most people with DS have sufficient neuropathology for an AD diagnosis. Interestingly, atherosclerosis and hypertension are atypical in DS with age, suggesting the lack of these vascular risk factors may be associated with reduced cerebrovascular pathology. However, becaus...
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ژورنال
عنوان ژورنال: Frontiers in Behavioral Neuroscience
سال: 2015
ISSN: 1662-5153
DOI: 10.3389/fnbeh.2015.00268