Dissecting the genetic determinants of hemostasis and thrombosis
نویسندگان
چکیده
منابع مشابه
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Determinants of PF4/heparin immunogenicity
Heparin-induced thrombocytopenia (HIT) is an antibody-mediated disorder that occurs with variable frequency in patients exposed to heparin. HIT antibodies preferentially recognize large macromolecular complexes formed between PF4 and heparin over a narrow range of molar ratios, but the biophysical properties of complexes that initiate antibody production are unknown. To identify structural dete...
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Genetic determinants of arterial thrombosis.
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We recently demonstrated that blockade of the platelet adhesion receptor glycoprotein (GP) Ib protects mice from ischemic stroke. Although von Willebrand factor (VWF) is the major ligand for GPIb , GPIb can engage other counterreceptors on endothelial cells, platelets, and leukocytes (eg, Mac-1 or P-selectin) potentially involved in stroke outcome. To further analyze whether VWF is of particula...
متن کاملThrombosis and Hemostasis
1Inserm, Unite 872, Centre de recherche des Cordeliers, Paris, France; 2Université Pierre et Marie Curie-Paris 6, Unite Mixte de Recherche S 872, Centre de recherche des Cordeliers, Paris, France; 3Université Paris Descartes, Unite Mixte de Recherche S 872, Centre de recherche des Cordeliers, Paris, France; and 4Department of Drug Discovery and Development, Italian Institute of Technology, Geno...
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ژورنال
عنوان ژورنال: Current Opinion in Hematology
سال: 2015
ISSN: 1065-6251
DOI: 10.1097/moh.0000000000000165