Distinct Requirements for Deletion versus Anergy during CD8 T Cell Peripheral Tolerance In Vivo
نویسندگان
چکیده
منابع مشابه
Distinct requirements for deletion versus anergy during CD8 T cell peripheral tolerance in vivo.
Activation of naive T cells by quiescent APCs results in tolerance through deletion and anergy. The underlying basis for these distinct fates is unclear. Using clone 4 TCR transgenic animals as a source of naive CD8 T cells, we examined the requirements for peripheral deletion in vivo. Our results demonstrate that independent of the amount of Ag used for stimulation, a single dose was insuffici...
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Intrathymic deletion of thymocytes with high af®nity for self antigen cells plays a crucial role in contracting the autoreactive T-cell repertoire. However, this is manifestly an incomplete process. Not all self proteins are effectively presented in the thymus, including those that are expressed well after the bulk of the T-cell repertoire has been formed, and it is relatively easy to detect au...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2005
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.174.4.2046