Distribution of plasminogen activator inhibitor in normal liver, cirrhotic liver, and liver with metastases.
نویسندگان
چکیده
منابع مشابه
Distribution of plasminogen activator inhibitor in normal liver, cirrhotic liver, and liver with metastases.
AIMS To examine the distribution of PAI-1 antigen in normal and cirrhotic liver and liver with metastases. METHODS Sections of normal and cirrhotic liver and liver with metastases were stained using the alkaline phosphatase antialkaline phosphatase (APAAP) technique and monoclonal antibody specific for plasminogen activator inhibitor (PAI-1). RESULTS PAI-1 antigen was identified as discrete...
متن کاملTissue plasminogen activator, plasminogen activator inhibitors, and activator-inhibitor complex in liver disease.
AIMS To identify the relative contribution of plasminogen activators, particularly tissue plasminogen activator (t-PA) and specific plasminogen activator inhibitors (PAI-1, PAI-2), to the fibrinolytic changes associated with various types of liver disease or severe chemical and physical damage to the liver. METHODS Platelet rich (PRP) and platelet poor plasma (PFP) from patients with alcoholi...
متن کاملEffect of saffron on liver metastases in patients suffering from cancers with liver metastases: A randomized, double blind, placebo-controlled clinical trial
Objective: Cancer represents the second cause of mortality in the world. Saffron as a medicinal plant is known for its anti-cancer and anti-depressant properties. In this randomized double blind clinical trial, the effects of saffron on response to treatment in patients suffering from liver metastasis were evaluated. Materials and Methods: Thirteen patients suffering from liver metastases who r...
متن کاملHepatobiliary excretion of silibinin in normal and liver cirrhotic rats.
Silibinin is the main biologically active flavonolignan extracted from the seeds and fruits of milk thistle and has potential efficacy in the treatment of liver disease. The aim of the present study was to examine the hepatobiliary excretion of silibinin and its effect on dimethylnitrosamine (DMN)-induced liver cirrhosis. The experiments were divided into five groups: 10, 30, and 50 mg/kg silib...
متن کاملCritical role of plasminogen activator inhibitor-1 in cholestatic liver injury and fibrosis.
Plasminogen activator inhibitor-1 (PAI-1) is an acute phase protein known to correlate with hepatic fibrosis. However, whether or not PAI-1 plays a causal role in this disease process had not been directly tested. Therefore, wild-type or PAI-1 knockout (PAI-1(-/-)) mice underwent bile duct ligation. Mice were sacrificed either 3 or 14 days after surgery for assessment of early (i.e., inflammati...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1994
ISSN: 0021-9746
DOI: 10.1136/jcp.47.3.218