Diverse cellular players orchestrate regeneration after wounding

Cellular Players in Skeletal Muscle Regeneration

Skeletal muscle, a tissue endowed with remarkable endogenous regeneration potential, is still under focused experimental investigation mainly due to treatment potential for muscle trauma and muscular dystrophies. Resident satellite cells with stem cell features were enthusiastically described quite a long time ago, but activation of these cells is not yet controlled by any medical interventions...

Cellular switches orchestrate rhythmic circuits

Small inhibitory neuronal circuits have long been identified as key neuronal motifs to generate and modulate the coexisting rhythms of various motor functions. Our paper highlights the role of a cellular switching mechanism to orchestrate such circuits. The cellular switch makes the circuits reconfigurable, robust, adaptable, and externally controllable. Without this cellular mechanism, the cir...

RNA assemblages orchestrate complex cellular processes

Eukaryotic mRNAs are monocistronic, and therefore mechanisms exist that coordinate the synthesis of multiprotein complexes in order to obtain proper stoichiometry at the appropriate intracellular locations. RNA-binding proteins containing low-complexity sequences are prone to generate liquid droplets via liquid-liquid phase separation, and in this way create cytoplasmic assemblages of functiona...

Regeneration of reptilian scales after wounding: neogenesis, regional difference, and molecular modules

Lizard skin can produce scales during embryonic development, tail regeneration, and wound healing; however, underlying molecular signaling and extracellular matrix protein expression remains unknown. We mapped cell proliferation, signaling and extracellular matrix proteins in regenerating and developing lizard scales in different body regions with different wound severity. Following lizard tail...

Interacting with TRPC1 after Wounding