Diverse cytoprotective actions of vitamin E isoforms- role as peroxyl radical scavengers and complementary functions with selenoproteins
نویسندگان
چکیده
Vitamin E, a generic term for tocopherol (T) and tocotrienol (T3), is one of the most potent lipid-soluble antioxidants in body. It classified into T T3 based on difference side chain structure. have four isoforms: ?-, ?-, ?-, ?, which different chroman rings. Both exhibit similar ability to scavenge free radicals, extent this depends However, they display unique cytoprotective activities cultured cells depending The effects vitamin E received much attention prevention ferroptosis, distinct form cell death involving iron-dependent lipid peroxidation. This review focuses actions isoforms against oxidative stress, particularly between its relation cellular uptake distribution. Moreover, molecular mechanism cytoprotection oxidation products explained, complementary role selenoproteins prevent peroxidation ferroptosis described. Furthermore, evaluation E's radical scavenging activity vivo using stress markers discussed, kinetic data physiological molar ratio substrates, limited as peroxyl scavenger future directions unresolved issues related are also discussed.
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2021
ISSN: ['1873-4596', '0891-5849']
DOI: https://doi.org/10.1016/j.freeradbiomed.2021.08.234