DNA damage by C1027 involves hydrogen atom abstraction and addition to nucleobases
نویسندگان
چکیده
منابع مشابه
Oxidation of DNA: damage to nucleobases.
All organisms store the information necessary to maintain life in their DNA. Any process that damages DNA, causing a loss or corruption of that information, jeopardizes the viability of the organism. One-electron oxidation is such a process. In this Account, we address three of the central features of one-electron oxidation of DNA: (i) the migration of the radical cation away from the site of i...
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3 C1+ HR -+ HC1+ R Reactions . . . . . . . . . . . . . . . . . . . . 3.
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We report a computational investigation of the hydrogen abstraction (H-abstraction) induced by triplet benzophenone ((3)BP) on thymine nucleobase and backbone sugar. The chemical process is studied using both high level multiconfigurational perturbation and density functional theory. Both methods show good agreement in predicting small kinetic barriers. Furthermore the behavior of benzophenone ...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry
سال: 2012
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2012.06.004