DNA methylation is stable during replication and cell cycle arrest
نویسندگان
چکیده
منابع مشابه
DNA methylation is stable during replication and cell cycle arrest
DNA methylation is an epigenetic modification with important functions in development. Large-scale loss of DNA methylation is a hallmark of cancer. Recent work has identified large genomic blocks of hypomethylation associated with cancer, EBV transformation and replicative senescence, all of which change the proportion of actively proliferating cells within the population measured. We asked if ...
متن کاملRegulation of DNA replication during the yeast cell cycle.
One central event that must occur exactly once per cell division cycle is the replication of the genomic DNA. One defining observation of the eukaryotic cell cycle is that the nuclear DNA replicates during a short period (the S phase) and that during that period each part of every chromosome is entirely replicated. Although there are many origins of DNA replication per chromosome, and it is kno...
متن کاملDNA replication: Controlling initiation during the cell cycle
The replication of the genome of a eukaryotic cell is a tightly regulated process. Firstly, replication is coordinated with general macromolecular synthesis, so that the DNA-to-protein ratio is maintained within a relatively narrow range. This involves a mechanism that couples the initiation of DNA replication to the achievement of a critical cell size. Secondly, replication generates exactly t...
متن کاملRole of DNA Methylation in Cell Cycle Arrest Induced by Cr (VI) in Two Cell Lines
Hexavalent chromium [Cr(IV)], a well-known industrial waste product and an environmental pollutant, is recognized as a human carcinogen. But its mechanisms of carcinogenicity remain unclear, and recent studies suggest that DNA methylation may play an important role in the carcinogenesis of Cr(IV). The aim of our study was to investigate the effects of Cr(IV) on cell cycle progress, global DNA m...
متن کاملCell cycle arrest at the initiation step of human chromosomal DNA replication causes DNA damage.
Cell cycle arrest in response to environmental effects can lead to DNA breaks. We investigated whether inhibition of DNA replication during the initiation step can lead to DNA damage and characterised a cell-cycle-arrest point at the replication initiation step before the establishment of active replication forks. This arrest can be elicited by the iron chelators mimosine, ciclopirox olamine or...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2015
ISSN: 2045-2322
DOI: 10.1038/srep17911