DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer

Role of DNA Replication Defects in Breast Cancer Role of DNA Replication Defects in Breast Cancer

Targeting DNA Replication Stress for Cancer Therapy

The human cellular genome is under constant stress from extrinsic and intrinsic factors, which can lead to DNA damage and defective replication. In normal cells, DNA damage response (DDR) mediated by various checkpoints will either activate the DNA repair system or induce cellular apoptosis/senescence, therefore maintaining overall genomic integrity. Cancer cells, however, due to constitutive g...

DNA replication stress and cancer chemotherapy

DNA replication is one of the fundamental biological processes in which dysregulation can cause genome instability. This instability is one of the hallmarks of cancer and confers genetic diversity during tumorigenesis. Numerous experimental and clinical studies have indicated that most tumors have experienced and overcome the stresses caused by the perturbation of DNA replication, which is also...

APOBEC3 Deletion is Associated with Breast Cancer Risk in a Sample of Southeast Iranian Population

Breast Cancer (BC) is considered as one of the most important causes of death worldwide. Previous studies showed that apolipoprotein B mRNA- editing catalytic polypeptide-like 3 (APOBEC3) gene deletion significantly increased the risk of BC risk in Chinese and European women. The present study aimed to assess the possible impact of APOBEC3 deletion and the risk of BC in a sample of Iranian popu...

The Effect of Stress Management Group Counseling on Stress in Women with a Family History of Breast Cancer

Background & Aims: Breast cancer is the most prevalent cancer and the leading cause of death due to cancer in woman. The presence of a breast cancer patient in the family not only increases the risk of this cancer among family members, but can also increase their stress level. Moreover, increased stress level can be proposed as a trigger for breast cancer. The aim of the present study was to ev...