Do COPD subtypes really exist? COPD heterogeneity and clustering in 10 independent cohorts
نویسندگان
چکیده
منابع مشابه
Chronic diseases like asthma and COPD: do they truly exist?
We have all been taught what asthma is and currently, the worldwide Global Initiative for Asthma (GINA) strategy defines the disease in great detail [1]. Similarly, chronic obstructive pulmonary disease (COPD) has been delineated carefully by the Global Initiative for Chronic Obstructive Lung Disease (GOLD), which provides concrete recommendations for its diagnosis based on today’s standards [2...
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Is there such a thing as a disease? For most doctors, the question may seem absurd, and barely worth a moment’s thought. Yet the question is a legitimate one, and is taken seriously by a range of people from biologists to philosophers. There are many reasons why. For example, as any doctor will recognise, the definitions of many diseases are quite arbitrary. They vary from one place to another,...
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I argue that the so-called psychological predicates like komapta 'thankful,' mwusepta 'fearful,' silhta `loathsome,' or kulipta 'missing' require a nominative subject and a locative or dative complement, challenging the claim, a conventional wisdom originated from Kuno(1973), that they are two-place "transitive adjectives" requiring a nominative direct object. I also show that those adjectives ...
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Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous disease and its definition as a disease characterised by a non completely reversible airflow obstruction mainly caused by cigarette smoke does not fully describe the variability in its clinical presentation. The main complain of patients with COPD is exertional dyspnea caused by hyperinflation [1]. Therefore, the basis ...
متن کاملThe Relationship between the Severity of Airway Obstruction and COPD Diagnostic Questionnaire Score in COPD Patients
Background & objectives: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and systemic inflammation which is also associated with pulmonary and extra-pulmonary complications. COPD Diagnostic Questionnaire (CDQ) is a valid questionnaire that is used to identify patients with COPD. The purpose of this study was to determine the relationship between ...
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ژورنال
عنوان ژورنال: Thorax
سال: 2017
ISSN: 0040-6376,1468-3296
DOI: 10.1136/thoraxjnl-2016-209846