Does regular treatment with ketotifen inhibit bronchoconstriction induced by isocapnic hyperventilation?
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چکیده
منابع مشابه
The relative contributions of histamine and prostanoids to bronchoconstriction provoked by isocapnic hyperventilation in asthma.
It has been proposed that exercise provokes bronchoconstriction in asthma by inducing mast cell degranulation, and that this occurs secondary to the hyperpnoea of exercise causing hypertonicity of the airway lining fluid. We investigated the contribution of the mast cell products, histamine and prostaglandins, to the bronchoconstriction induced by isocapnic hyperventilation (ISH) using single d...
متن کاملTracheobronchial constriction in asthmatics induced by isocapnic hyperventilation with dry cold air.
Although it is well known that isocapnic hyperventilation (IHV) with dry cold air produces airway constriction in asthmatic subjects, the site of airway narrowing is nuclear. To address this issue, we have quantified the tracheal and bronchial response to IHV with dry cold air in 15 patients with mild asthma and 7 healthy control subjects. We employed the acoustic reflection technique to evalua...
متن کاملMucosal injury and eicosanoid kinetics during hyperventilation-induced bronchoconstriction.
Bronchoalveolar lavage (BAL) of canine peripheral airways was performed at various times after hyperventilation, and BAL fluid (BALF) cell and mediator data were used to evaluate two hypotheses: 1) hyperventilation-induced mucosal injury stimulates mediator production, and 2) mucosal damage is correlated with the magnitude of hyperventilation-induced bronchoconstriction. We found that epithelia...
متن کاملBronchoconstriction induced by hyperventilation with humidified hot air: role of TRPV1-expressing airway afferents.
A recent study by our laboratory has shown that an increase in intrathoracic temperature activates vagal pulmonary C-fibers. Because these afferents are known to elicit reflex bronchoconstriction upon stimulation, this study was carried out to investigate if an increase in airway temperature within the physiological range alters bronchomotor tone. Adult guinea pigs were anesthetized and mechani...
متن کاملAttenuation of isocapnic hyperpnoea-induced guinea-pig bronchoconstriction by chronic hypoxia.
Chronic hypoxia has been shown to augment the production of antioxidants in rat lungs and to reduce airway hyperreactivity in patients with asthma. This study investigated indirectly whether this increase in antioxidants occurs in guinea-pig lungs and whether the increased antioxidants affect hyperpnoea-induced bronchoconstriction (HIB). Guinea-pigs were divided into four groups: control (n=8);...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1987
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1987.tb03143.x