Does stopping left-right nodal flow mirror impaired mechanosensation in the left-right organizer?
نویسندگان
چکیده
منابع مشابه
Physical limits of flow sensing in the left-right organizer
Fluid flows generated by motile cilia are guiding the establishment of the left-right asymmetry of the body in the vertebrate left-right organizer. Competing hypotheses have been proposed: the direction of flow is sensed either through mechanosensation, or via the detection of chemical signals transported in the flow. We investigated the physical limits of flow detection to clarify which mechan...
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The striking left-right asymmetry of visceral organs is known to depend on left- and right-side-specific cascades of gene expression during early embryogenesis. Now, developmental biologists are characterizing the earliest steps in asymmetry determination that dictate the sidedness of asymmetric gene expression. The proteins and structures involved control fascinating physiological processes, s...
متن کاملNodal Flow and the Generation of Left-Right Asymmetry
The establishment of left-right asymmetry in mammals is a good example of how multiple cell biological processes coordinate in the formation of a basic body plan. The leftward movement of fluid at the ventral node, called nodal flow, is the central process in symmetry breaking on the left-right axis. Nodal flow is autonomously generated by the rotation of cilia that are tilted toward the poster...
متن کاملOrganizer induction determines left-right asymmetry in Xenopus.
Vertebrates appear bilaterally symmetrical but have considerable left-right (LR) asymmetry in the anatomy and placement of internal organs such as the heart. Although a number of asymmetrically expressed genes are known to affect LR patterning, both the initial source of asymmetry and the mechanism that correctly orients the LR axis remain controversial. In this study, we show that the inductio...
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ژورنال
عنوان ژورنال: Cilia
سال: 2015
ISSN: 2046-2530
DOI: 10.1186/2046-2530-4-s1-p39