Does the Wall Stress Alone Stimulate the Natriuretic Peptide System?
نویسندگان
چکیده
منابع مشابه
Natriuretic peptide system in the human retina.
PURPOSE The natriuretic peptide (NP) family includes atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). Natriuretic peptides are known to inhibit vascular cell growth and regulate vessel tone. There is also much evidence to suggest they modulate vascular permeability and angiogenesis, as well as regulating aqueous humor production in the eye...
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Numerous clinical studies have addressed the role of the natriuretic peptide system either as a diagnostic tool or as a guide to treatment in many cardiac diseases. The concept behind these studies has been that intravascular overload produces cardiac wall stress that alone stimulates the synthesis and release of natriuretic peptides the result of which is diuresis, natriuresis, and vasodilatat...
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Article history: Received 2 March 2017 Accepted 2 March 2017 Available online 3 March 2017 on ANP secretion independently of insulin and glucagon levels. In this issue of EBioMedicine, Zois et al. (2017-in this issue) aimed to assess this question in a series of clinical studies in healthy individuals with normal and impaired glucose tolerance. In a first experimental study, they examined cardi...
متن کاملWall stress modulates brain natriuretic peptide production in pressure overload cardiomyopathy.
OBJECTIVES We postulated that both diastolic and systolic load modulate B-type natriuretic peptide (BNP) production in human pressure overload hypertrophy/failure. BACKGROUND In isolated myocytes, diastolic stretch induces BNP messenger ribonucleic acid expression. However, the mechanism of the BNP release in human hypertrophy remains controversial. METHODS In 40 patients with symptomatic a...
متن کاملAtrial and brain natriuretic peptides stimulate the production and secretion of C-type natriuretic peptide from bovine aortic endothelial cells.
C-type natriuretic peptide (CNP) is a member of the natriuretic peptide family which is produced in vascular endothelial cells and may play an important paracrine role in the vasaculature. We sought to determine the regulation of CNP production by other vasoactive peptides from cultured aortic endothelial cells. The vasoconstrictors endothelin-1 and angiotensin II had little effect on the basal...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2010
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.110.162628