Does Uremia Cause Vascular Dysfunction?
نویسندگان
چکیده
منابع مشابه
Does Uremia Cause Vascular Dysfunction?
Vascular dysfunction induced by uremia has 4 main aspects. (1) Atherosclerosis is increased. Intima-media thickness is increased, and animal studies have established that uremia accelerates atherosclerosis. Uremic toxins are involved in several steps of atherosclerosis. Leukocyte activation is stimulated by guanidines, advanced glycation end products (AGE), p-cresyl sulfate, platelet diadenosin...
متن کاملDoes uremia cause vascular dysfunction?
Vascular dysfunction induced by uremia has 4 main aspects. (1) Atherosclerosis is increased. Intima-media thickness is increased, and animal studies have established that uremia accelerates atherosclerosis. Uremic toxins are involved in several steps of atherosclerosis. Leukocyte activation is stimulated by guanidines, advanced glycation end products (AGE), p-cresyl sulfate, platelet diadenosin...
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Asymmetric dimethylarginine (ADMA) is an endogenous and competitive inhibitor of nitric oxide synthase. Plasma levels of this inhibitor are elevated in patients with atherosclerosis and in those with risk factors for atherosclerosis. In these patients, plasma ADMA levels are correlated with the severity of endothelial dysfunction and atherosclerosis. By inhibiting the production of nitric oxide...
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In the past two decades, there has been a 2to 4-fold increase in childhood obesity in the United States. The current epidemic of childhood obesity in the United States can be expected to cause a surge in cardiovascular disease in this generation.1,2 Already, obesity-related illnesses account for nearly 300 000 deaths and about $100 billion in economic costs per year in the United States. Theref...
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Autonomic nervous system dysfunction is a common feature in uremia and may have a number of clinical sequelae. Simple cardiovascular reflex screening can be performed in patients during conservative treatment, on periodic dialysis therapy, or after kidney transplantation to diagnose and follow up autonomic function impairment. Other approaches, such as heart-rate variability studies in the freq...
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ژورنال
عنوان ژورنال: Kidney and Blood Pressure Research
سال: 2011
ISSN: 1423-0143,1420-4096
DOI: 10.1159/000327131