Dual defensin strategy for targeting Enterococcus faecalis
نویسندگان
چکیده
منابع مشابه
Dual defensin strategy for targeting Enterococcus faecalis.
A leading cause of antibiotic-resistant hospital infection (1), Enterococcus faecalis, decorates its surface with proteins that contribute to its ability to colonize and survive. Several proteins, including Esp (2), aggregation substance (3), a collagen adhesin (4), and a pilin (5), correlate with a particular disease or exacerbate the course of infection in amodel system. In PNAS, Kandaswamy e...
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Virulence factor secretion and assembly occurs at spatially restricted foci in some Gram-positive bacteria. Given the essentiality of the general secretion pathway in bacteria and the contribution of virulence factors to disease progression, the foci that coordinate these processes are attractive antimicrobial targets. In this study, we show in Enterococcus faecalis that SecA and Sortase A, req...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2013
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1319939110