Dynamic changes of miRNAs in skeletal muscle development at New Zealand rabbits

نویسندگان

چکیده

Abstract Background miRNA is one of the crucial roles in complex and dynamic network that regulates development skeletal muscle. The landscape muscle miRNAs from fetus to adult New Zealand rabbits has not been revealed yet. Results In this study, nine RNA-seq libraries fetus, child rabbits’ leg muscles were constructed. A total 278 differentially expressed (DEmiRNAs) identified. vs. group, main functional enrichments involved membrane transport. Pathway enriched terms up-regulated DEmiRNAs connected with differentiation hypertrophy muscle, down-regulated ones related structure metabolic capacity. functions associated positioning transportation, pathways relevant ECM, hypertrophy. Finally, ocu-miR-185-3p ocu-miR-370-3p, which had most target genes, identified as hub-miRNAs these two groups. Conclusions short, we summarized highly uniquely muscles. Besides, potential changes consecutive stages have explored. Among them, ocu-miR-370-3p genes selected hub-miRNAs. These data improved understanding regulatory molecules meat rabbit development, provided a novel perspective for molecular breeding rabbits.

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ژورنال

عنوان ژورنال: BMC Genomics

سال: 2021

ISSN: ['1471-2164']

DOI: https://doi.org/10.1186/s12864-021-07896-5