Dynamic hydraulic flow stimulation on mitigation of trabecular bone loss in a rat functional disuse model
نویسندگان
چکیده
منابع مشابه
Comparison of oscillatory muscle stimulation and dynamic hydraulic flow stimulation on musculoskeletal adaptation in a rat functional disuse model
INTRODUCTION Mechanotransductive signals through fluid flow stimulation, e.g., intramedullary pressure (ImP), have been shown effective in bone adaptation. ImP distribution is suggested to influence the mechanotransductory signals within bones. Suggested by the muscle pump theory, muscle compressions may increase vessel pressure gradient that can directly increase ImP. To further elucidate the ...
متن کاملElectrical stimulation of denervated rat skeletal muscle retards trabecular bone loss in early stages of disuse musculoskeletal atrophy.
OBJECTIVES We aimed to determine the intensity of muscle stimulation required to prevent structural failure as well as bone and skeletal muscle loss after denervation-induced disuse. METHODS Seven-week-old rats (weight, 198-225 g) were randomly assigned to age-matched groups comprising control (CON), sciatic nerve denervation (DN) or direct electrical stimulation (ES) one day later [after den...
متن کاملComparison of morphological changes of muscle fibers in response to dynamic electrical muscle contraction and dynamic hydraulic stimulation in a rat hindlimb disuse model.
This study attempted to compare the muscle fiber morphological responses to dynamic electrical muscle stimulation (DEMS) and dynamic hydraulic stimulation (DHS) in rats under hindlimb suspension (HLS). DEMS at 1 Hz, 50 Hz and 100 Hz for 10 min/day, 5 days/week were introduced to the animals' right quadriceps. Static and 2 Hz DHS were introduced to the right tibiae of other animal groups on a "1...
متن کاملIntramedullary Pressure Induced by Dynamic Hydraulic Stimulation and its Potential in Attenuation of Bone Loss
INTRODUCTION: Bone fluid flow has been demonstrated as a critical regulator in mechanotransductive signaling and bone adaptation. Intramedullary pressure (ImP) is suggested to initiate bone fluid flow and influence the osteogenic signals within bone. The potential ImP-induced bone fluid flow then triggers the remodeling process in the skeleton . It has been demonstrated that ImP generated by os...
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ژورنال
عنوان ژورنال: Bone
سال: 2012
ISSN: 8756-3282
DOI: 10.1016/j.bone.2012.06.030