Dynamic Importance Sampling Calculations on ECD Epitelial Growth Factor Receptor Conformational Changes
نویسندگان
چکیده
منابع مشابه
Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface.
Structural studies have shown that ligand-induced epidermal growth factor receptor (EGFR) dimerization involves major domain rearrangements that expose a critical dimerization arm. However, simply exposing this arm is not sufficient for receptor dimerization, suggesting that additional ligand-induced dimer contacts are required. To map these contributions to the dimer interface, we individually...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2011
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2010.12.1613