Dysfunction of Endothelial Nitric Oxide Synthase and Atherosclerosis
نویسندگان
چکیده
منابع مشابه
Dysfunction of endothelial nitric oxide synthase and atherosclerosis.
Atherosclerosis is associated with an impairment of endothelium-dependent relaxations, which represents the reduced bioavailability of nitric oxide (NO) produced from endothelial NO synthase (eNOS). Among various mechanisms implicated in the impaired EDR in atherosclerosis, superoxide generated from dysfunctional eNOS has attracted attention. Under conditions in which vascular tissue levels of ...
متن کاملDyfunction of Endothelial Nitric Oxide Synthase and Atherosclerosis
Atherosclerosis is associated with an impairment of endothelium-dependent relaxations, which represents the reduced bioavailability of nitric oxide (NO) produced from endothelial NO synthase (eNOS). Among various mechanisms implicated in the impaired EDR in atherosclerosis, superoxide generated from dysfunctional eNOS has attracted attention. Under conditions in which vascular tissue levels of ...
متن کاملAtherosclerosis and the two faces of endothelial nitric oxide synthase.
Atherosclerosis and the Two Faces of Endothelial Nitric Oxide Synthase Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 1998 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.97.1.108 1998;97:108-112 Circulation. http://circ.ahajournals.org/content/97/1/108 World...
متن کاملSeinosuke Kawashima and Mitsuhiro Yokoyama Dysfunction of Endothelial Nitric Oxide Synthase and Atherosclerosis
Atherosclerosis is associated with an impairment of endothelium-dependent relaxations, which represents the reduced bioavailability of nitric oxide (NO) produced from endothelial NO synthase (eNOS). Among various mechanisms implicated in the impaired EDR in atherosclerosis, superoxide generated from dysfunctional eNOS has attracted attention. Under conditions in which vascular tissue levels of ...
متن کاملFolic acid reverts dysfunction of endothelial nitric oxide synthase.
5-methyltetrahydrofolate (MTHF), the active form of folic acid, has been reported to restore NO status in hypercholesterolemic patients. The mechanism of this effect remains to be established. We assessed the effects of L- and D-MTHF on tetrahydrobiopterin (BH(4))-free and partially BH(4)-repleted endothelial NO synthase (eNOS). Superoxide production of eNOS and the rate constants for trapping ...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2004
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.0000125114.88079.96