Early Iron Deficiency Alters Sensorimotor Development and Brain Monoamines in Rats
نویسندگان
چکیده
منابع مشابه
Early-Life Iron Deficiency Reduces Brain Iron Content and Alters Brain Tissue Composition Despite Iron Repletion: A Neuroimaging Assessment
Early-life iron deficiency has lifelong influences on brain structure and cognitive function, however characterization of these changes often requires invasive techniques. There is a need for non-invasive assessment of early-life iron deficiency with potential to translate findings to the human clinical setting. In this study, 28 male pigs were provided either a control diet (CONT; n = 14; 23.5...
متن کاملEarly-life iron deficiency anemia alters neurotrophic factor expression and hippocampal neuron differentiation in male rats.
Fetal-neonatal iron deficiency alters hippocampal neuronal morphology, reduces its volume, and is associated with acute and long-term learning impairments. However, neither the effects of early-life iron deficiency anemia on growth, differentiation, and survival of hippocampal neurons nor regulation of the neurotrophic factors that mediate these processes has been investigated. We compared hipp...
متن کاملIron deficiency, febrile seizures and brain development.
Iron deficiency anemia is one of the most prevalent micronutrient deficiencies in young children in India and other parts of the world, and it is strongly associated with persistent cognitive and motor delays even after the anemia and iron deficit have been repaired. Madan, et al. [1] reported recently that children aged 6-23 months with moderate to severe iron deficiency anemia had lower menta...
متن کاملRegional brain iron, ferritin and transferrin concentrations during iron deficiency and iron repletion in developing rats.
Iron deficiency in young rats leads to a decrease in brain iron and ferritin concentrations, an increase in transferrin (Tf) concentration, and an increased rate of uptake of iron from the plasma pool. We conducted two experiments to determine whether brain iron, Tf and ferritin respond quickly to iron repletion and to determine whether brain regions respond heterogeneously. Weanling male Sprag...
متن کاملPersistent neurochemical and behavioral abnormalities in adulthood despite early iron supplementation for perinatal iron deficiency anemia in rats.
BACKGROUND Iron deficiency anemia (IDA) has been associated with altered cognitive, motor, and social-emotional outcomes in human infants. We recently reported that rats with chronic perinatal IDA, had altered regional brain iron, monoamines, and sensorimotor skill emergence during early development. OBJECTIVE To examine the long-term consequences of chronic perinatal IDA on behavior, brain i...
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ژورنال
عنوان ژورنال: The Journal of Nutrition
سال: 2007
ISSN: 0022-3166,1541-6100
DOI: 10.1093/jn/137.1.118