Editorial overview: Mechanistic toxicology

PHARMACOLOGY AND TOXICOLOGY Editorial

Citation: Vsevolod V Gurevich. “Welcome to the New Journal!” EC Pharmacology and Toxicology 1.1 (2015): 1-4. New classes of drugs are being developed along with conventional ones. For example, G protein-coupled receptors (GPCRs) are now targeted not only by orthosteric ligands (that bind where the natural ligand does), which can be activators (agonists), neutral antagonists, which bind at the s...

Editorial: Drug Metabolism and Toxicology

A drug metabolism study is an important aspect of the early drug discovery and development process [1,2]. In order to improve the understanding of drug efficacy and safety characteristics, it is desirable to investigate the drug metabolism in animals or humans [3,4]. These metabolism studies involve metabolic stability, cytochrome P-450 (CYP-450) induction or inhibition and metabolite identific...

Overview of inhalation toxicology.

The development of inhalation toxicology as a distinct discipline can be traced back well over one hundred years. The technology has advanced in terms of materials and designs used to construct inhalation chambers and the equipment used to generate controlled test atmospheres of a wide variety of gases, vapors, dusts, and droplets. Consideration of metered dose inhalers, a relatively recent con...

Neurochemistry and toxicology: overview.

We have witnessed a tremendous increase in our knowledge of the molecular and biochemical mechanisms which underly the activities of the nervous system. Such knowledge is essential in order to determine the basic mechanisms involved in neurotoxic events. An overview of how neurotoxins could conceivably interfere with some basic neurochemical processes is presented, along with a specific example...

Editorial overview.