Effect of captopril and hydralazine on arterial pressure-urinary output relationships in spontaneously hypertensive rats.

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effect of captopril and hydralazine on arterial pressure-urinary output relationships in spontaneously hypertensive rats.

Angiotensin I converting enzyme inhibitors are typically classified as peripheral vasodilators. We studied the effect of captopril and a known vasodilator, hydralazine, on arterial pressure-urinary output relationships in adult spontaneously hypertensive rats to determine whether these drugs produced similar changes in this relationship. Tail-cuff pressure and 24-hour urine output and sodium ex...

متن کامل

Arterial pressure and exaggerated natriuresis in spontaneously hypertensive rats.

We tested the hypothesis that the exaggerated natriuretJc response of spontaneously hypertensive rats (SHR) to intragastric volume expansion may be independent of the sustained level of arterial pressure. The SHRs were treated for 10 days with guanethldine S04, 25 mg/llter, and hydralazine HO, 80 mg/liter, in drinking water. Mean arterial pressure (MAP) in conscious treated SHRs (T-SHR) was 130...

متن کامل

Long-term microvascular response to hydralazine in spontaneously hypertensive rats.

Chronic microcirculatory alterations produced by prolonged use of a vasoactive drug were repeatedly observed in the same skeletal muscle vessels of the dorsal microcirculatory chamber. Arterioles and venules with diameters averaging from 70 to 90 microns, the size range contributing most to peripheral vascular resistance, were measured daily for 6 days to determine differences in diameter, tort...

متن کامل

Effect of captopril on some ventricular contractility indices in spontaneously hypertensive rats (SHR).

Two groups of SHR were treated with captopril (Squibb): the first group (1 month old)--30 mg/kg i.p. twice daily for 77 days, and the second group (8 months old)--20 mg/kg p.o. twice a day for 23 days. The recording of electrocardiogram (ECG), systolic blood pressure (SBP), diastolic blood pressure (DBP), and some isometric indices of the left-ventricular contractility indicate that in all trea...

متن کامل

Effect of captopril on converting enzyme activity in chemically sympathectomized, spontaneously hypertensive rats.

Effect of subacute angiotensin converting enzyme (ACE) blockade on the converting enzyme activity (ACE activity) in plasma, aorta, lung, kidney and whole brain was evaluated in chemically-sympathectomized (with 6-hydroxydopamine) normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) using captopril given peripherally via the intraperitoneal (i.p) route and centrally through ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Hypertension

سال: 1987

ISSN: 0194-911X,1524-4563

DOI: 10.1161/01.hyp.10.6.590