EFFECT OF G.ATROVIRIDIS LEAF EXTRACT ON HEPAR STEATOSIS IN RATTUS NORVEGICUS OBES WITH A HIGH-FAT DIET

Garcinia atroviridis dikenal sebagai asam gelugur sudah sejak lama digunakan manusia rempah dan obat tradisional. Manfaatnya berhubungan dengan senyawa metabolit sekunder bioaktivitas anti-obesitas, anti-inflamasi, anti mikroba, antioksidan kanker. Kandungan lemak berlebih dalam darah dapat memicu peningkatan radikal bebas dan penurunan aktivitas antioksidan sehingga menimbulkan stres oksidatif, yang selanjutnya menyebabkan kerusakan hepar terjadinya perubahan struktur histologis berupa steatosis. Penelitian ini menggunakan rancangan posttest, randomized control group design. Kebaruan penelitian karena meneliti tentang pengaruh ekstrak daun G.atroviridis terhadap steatosis pada Rattus norvegicus obes diet tinggi lemak. bertujuan untuk mengetahui berbagai kadar G. gambaran histopatologis diberi (DTL), dibandingkan pemberian Pioglitazon DTL atau hanya normal. Temuan menunjukkan bahwa kelompok III penerima 10gr memiliki tingkat terbesar (70-80%, rata-rata 74%), sedangkan V 30gr terendah (30-45%, rata-rata). 35,6%). PIO Kelompok II (25-32 persen berarti 28 persen). Kesimpulan (30% -45% 35,6%) terbukti jaringan hati lebih rendah, menghasilkan temuan serupa (rata-rata 25-32 persen) %). Kata kunci: Diet Tinggi Lemak, atroviridis, Obese, Steatosis AbstractGarcinia known as has long been used by human a spice and traditional medicine. Its benefits are associated with secondary metabolite compounds bioactivity anti-obesity, anti-inflammatory, anti-microbial, antioxidant anti-cancer. Obesity is condition of the body containing too much fat due to an imbalance calories intake. low-level inflammation which at risk cardiovascular disease, type 2 diabetic mellitus, dyslipidemia, non-alcoholic fatty liver disease. Excess content in blood can trigger increase free radicals and decrease activity, causing oxidative stress, further causes damages changes structure histologic picture forming This study The novelty this because it examines effect leaf extract on high-fat diet.This aims determine various levels leaves histopathological obese High Fat (HFD) compared administration pioglitazon HFD or only standart diet. findings indicated that recipients had greatest average while lowest 35.6%). Group percent mean ). In I formulations, was not seen. 35.6%) shown have histological appearance tissue lower degree steatosis, yielding similar average) 28%).Keywords: Diet, Steatosis