Effect of microsatellite instability on histopathological parameters and prognosis in colon cancers

Purpose: The aim of this study was to compare the clinicopathological features, while evaluating frequency MSI, and survival rates in these patients our patient group with MSI microsatellite stabil (MSS) colorectal carcinomas (CRCs).Materials Methods: We retrospectively enrolled 146 who underwent colon resection between years 2014-2022. expression status evaluated by immunohistochemistry. association status, presense tumor-infiltrating lymphocytes (TILs), tumor budding score a patient’s assessed Kaplan–Meier method Cox regression analysis.Results: There were 104 (71.2%) MSS cases and, 42 (28.8%) cases. 15 (10.3%) tumors found be MSI-low, 27 (18.5%) MSI-high. significantly associated younger (<50), earlier stage (T1-T2), right localization, lower rate lymph node metastasis, presence mucinous component TILs response. Cox-regression model revealed TILs, score, are variables that affect survival. exhibited protective effect (Hazard ratio (HR)=0.446), which decreased mortality risk 2.24 times for follow-up period, high TBS increased HR=3.22.Conclusion: This CRCs may show unique features should using some guiding parameters will improve