Effect of Neoadjuvant Therapies on Soft Tissue Sarcomas with Tail-like Lesions: A Multicenter Retrospective Study

Several types of soft tissue sarcomas have peripheral infiltrative growth characteristics called tail-like lesions. The efficacy neoadjuvant therapy for tumors with lesions has not been elucidated. From 2012 to 2019, we analyzed 36 patients sarcoma treated therapy, including chemotherapy, radiotherapy, or both. effect on the tail sign was investigated by analyzing change in during and histological responses. median length lesion reduced from 29.5 mm at initiation 19.5 after therapy. extent shrinkage related histopathological responses main part tumor. Complete disappearance observed 12 patients; however, it achieving a microscopically negative margin. oncologic outcomes did significantly differ between cases without complete This study indicated that significant resection improvements clinical outcomes. A more comprehensive evaluation is needed elaborate surgical strategy.