Effectiveness and Efficiency of Imperfect Therapeutic HSV-2 Vaccines
نویسندگان
چکیده
منابع مشابه
Effectiveness and efficiency of imperfect therapeutic HSV-2 vaccines.
BACKGROUND Efforts are currently underway to develop therapeutic vaccines for Herpes Simplex Virus type 2 (HSV-2). METHODS We use a mathematical model to predict the potential public health impact of imperfect, therapeutic HSV-2 vaccines. We evaluate vaccine effectiveness and efficiency for the general population in the United States where HSV-2 prevalence is currently 22%. We assume that the...
متن کاملPopulation level impact of an imperfect prophylactic HSV-2 vaccine
Vaccine and Infectious Disease Institute, Program in Biostatistics and Biomathematics, and Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America Division of infectious diseases, Department of Biostatistics, Department of Medicine, Departments of Epidemiology, Virology Research Clinic, and Department of Laboratory Medicine, University o...
متن کاملProtection from herpes simplex virus (HSV)-2 infection with replication-defective HSV-2 or glycoprotein D2 vaccines in HSV-1-seropositive and HSV-1-seronegative guinea pigs.
BACKGROUND A herpes simplex virus (HSV)-2 candidate vaccine consisting of glycoprotein D (gD2) in alum and monophosphoryl lipid A (MPL) reduced genital herpes disease in HSV-1-seronegative women but not in men or HSV-1-seropositive women. METHODS To determine the effect of HSV-1 serostatus on effectiveness of different vaccines, we tested gD2 in alum/MPL, gD2 in Freund's adjuvant, and dl5-29 ...
متن کاملHerpes simplex virus (HSV) type 2 glycoprotein D subunit vaccines and protection against genital HSV-1 or HSV-2 disease in guinea pigs.
In two recent clinical trials, a vaccine containing herpes simplex virus (HSV) type 2 glycoprotein D (gD2) and a novel adjuvant AS04 comprising alum (Al) and 3-deactylated monophosphoryl lipid A (3-dMPL) afforded HSV-seronegative women significant protection against HSV-2 genital disease (vaccine efficacy, 73% in study 1 and 74% in study 2) and limited protection against infection (46% in study...
متن کاملEffectiveness of Imperfect Decoys
Mathematical relations are developed to express the effectiveness of decoys in a situation which requires the attacker to assign his weapons on the basis of imperfect classification of the targets. The analysis considers the effects of a number of pertinent parameters, such as the number of real and decoy targets and the enemy's classification ability and missile effectiveness, and calculates t...
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ژورنال
عنوان ژورنال: Human Vaccines
سال: 2007
ISSN: 1554-8600,1554-8619
DOI: 10.4161/hv.4529