Effects of Growth Hormone-Releasing Hormone (GRF) Analogs, Bovine and Rat GRF on Growth Hormone Secretion in Cattle In Vivo.
نویسندگان
چکیده
منابع مشابه
Characteristics of growth hormone response to the administration of growth hormone-releasing hormone (GRF) in the lamb.
Human growth hormone releasing hormone (GRF 1-44 or GRF 1-29) was administered to lambs at two different physiological stages (suckling: 5-6 week-old and weaned: 14-15 week-old) when growth hormone (GH) secretory patterns were different: suckling lambs exhibited flat basal GH profiles (5-10 ng/ml) while the weaned lambs had frequent spontaneous episodes of GH release (15-65 ng/ml). The iv injec...
متن کاملHypothalamic growth hormone-releasing factor (GRF) regulates its own receptor gene expression in vivo in the rat pituitary.
peptide that specifically stimulates both synthesis and secretion of pituitary GH [1]. GRF is released into the hypophyseal-portal vessels under control by a variety of neurotransmitters and neuropeptides. After reaching the pituitary, GRF binds to its specific receptors [1] on somatotrophs and generates bursts of GH secretion episodically [2]. Earlier ligand-binding and functional studies in r...
متن کاملPulsatile growth hormone secretion persists in genetic growth hormone-releasing hormone resistance.
Growth hormone (GH) secretion is regulated by GH-releasing hormone (GHRH), somatostatin, and possibly ghrelin, but uncertainty remains about the relative contributions of these hypophysiotropic factors to GH pulsatility. Patients with genetic GHRH receptor (GHRH-R) deficiency present an opportunity to examine GH secretory dynamics in the selective absence of GHRH input. We studied circadian GH ...
متن کاملResponse of growth hormone release to human growth hormone-releasing factor and its analogs in the bovine.
Responses of growth hormone (GH) release to synthetic human growth hormone-releasing factor (hGRF)-44-NH2 analogs were determined, and the GH-releasing potency based on dose per kg of body weight (bw) was compared with that of hGRF-44-NH2 in female dairy calves. Four- and 12-month-old calves were injected intravenously with 0.25 microgram of hGRF-44-NH2 or its analogs per kg of bw. Blood sample...
متن کاملGrowth hormone releasing hormone or growth hormone treatment in growth hormone insufficiency?
Sixteen prepubertal children who were insufficient for growth hormone were treated with growth hormone releasing hormone (GHRH) 1-40 and GHRH 1-29 for a mean time of nine months (range 6-12 months) with each peptide. Eleven children received GHRH 1-40 in four subcutaneous nocturnal pulses (dose 4-8 micrograms/kg/day) and eight (three of whom were also treated with GHRH 1-40) received GHRH 1-29 ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Endocrine Journal
سال: 1997
ISSN: 0918-8959,1348-4540
DOI: 10.1507/endocrj.44.811