Effects of Loading-Dose Statins Combined with PCSK9 Inhibitor Pre-Treatment before Primary Percutaneous Coronary Intervention on the Short-Term Prognosis in Patients with ST-Segment Elevation Myocardial Infarction

Objective: This study was aimed at investigating the effects of preoperative treatment with a loading dose statins combined PCSK9 inhibitor on coronary blood perfusion and short-term cardiovascular adverse events in patients ST-segment elevation myocardial infarction (STEMI). Method: Sixty-five STEMI who had visited Shanxi Cardiovascular Disease Hospital between May 2018 2021 were enrolled study. The no history oral or antiplatelet therapy. divided into group (loading inhibitors, 35 patients) routine only, 30 patients). primary endpoints thrombolysis (TIMI) flow grading, corrected TIMI frame count (CTFC), grading (TMPG), immediately after days operation. secondary endpoint composite death, nonfatal infarction, target vessel revascularization Results: significantly lower CTFC (14.09±8.42 vs 26±12.42, P=0.04) better TMPG (2.74±0.61 2.5±0.73, than Similarly, (16.29±7.39 26.23±11.53, (2.94±0.24 2.76±0.43, P=0.01) 1 month Conclusion: Preoperative high-intensity inhibitors increased emergency thrombus aspiration STEMI. However, did not decrease incidence revascularization.