Effects of repetitive transcranial magnetic and deep brain stimulation on long‐range synchrony of oscillatory activity in a rat model of developmental schizophrenia

Abstract Aberrant neuronal network activity likely resulting from disturbed interactions of excitatory and inhibitory systems may be a major cause cognitive deficits in neuropsychiatric diseases, like within the spectrum schizophrenic phenotypes. In particular, synchrony pattern oscillatory brain appears to limbic networks, e.g. between prefrontal cortex hippocampus. rat model maternal immune activation (MIA), we compared acute effects deep stimulation either medial or ventral hippocampus with repetitive transcranial magnetic (rTMS), using intermittent theta‐burst protocol (iTBS), on structures. Simultaneous local field potential recordings were made cortex, hippocampus, nucleus accumbens rostral part tegmental area before after anaesthetized rats previously (~3 h) treated sham verum rTMS. We found waxing waning theta gamma all structures which was less synchronous particular MIA offspring. Deep pre‐treatment iTBS‐rTMS partly improved this pattern. Gamma‐theta cross‐frequency coupling stronger offspring could reduced by cortex. can confirm aberrant model, at least normalizing neuromodulatory methods. It has proven whether these procedures have chronic suitable for therapeutic purposes.