Effects of selenium-enriched prebiotic on the growth performance, innate immune response, oxidative enzyme activity and microbiome of rainbow trout (Oncorhynchus mykiss)

Using prebiotics as functional ingredients in aquafeed is an emerging approach to prevent disease and improve fish production. This study explored the effect of supplementing with selenium-enriched prebiotic on growth performance, plasma lysozyme activity, oxidative enzymes activities various tissues rainbow trout, Oncorhynchus mykiss. The scale intestinal microbiomes were also characterized. A genetically- modified, whole-cell inactivated Schizosaccharomyces pombe that produces a novel form selenium called selenoneine was used supplement this study. Selenoneine selenium-containing molecule antioxidant suggesting it has potential production when ingredient aquafeeds. To investigate if S. can strengthen metrics, modulate surface internal microbiome, health status fish, 8-week feeding trial conducted. commercial feed supplemented no addition (control), 5 g Kg−1 (0.5%), or 10 (1.0%) pombe. Fish harvested at middle (week 4) end 8). There significant differences (p > 0.05) food conversion ratio, condition factor, survival during trial. microbiome remained stable experiment. No observed performance week 4; however, 8 fed 0.5% yeast had significantly higher weight gain < 0.05), hepatosomatic index, viscerosomatic index than control 1.0% diets. At 4, concentration diet. glutathione peroxidase activity liver, kidney, experimental diets two different sampling times. However, superoxide dismutase diet 4. 8, both led increases compared demonstrates supplementation selenoneine-producing growth, immune response, fish. Thus, holds promising enhance sustainability within aquaculture industry.