Effects of Zhuyu Annao on Hippocampal Neuronal Apoptosis and Cognitive Disorder in a Rat Model of Ischemic Brain Injury

نویسندگان

چکیده

Introduction We aimed to determine the effects of Zhuyu Annao (ZYAN) prescription on hippocampal neuronal apoptosis and cognitive disorder (CD) in ischemic brain injury (IBI). Material methods The improved Rice-Vannucci method was used prepare a rat model IBI. Rats ZYAN group were intragastrically administered 12.50 g/kg 4 h after modeling; rats mock surgical (MSG) (MG) an intraperitoneal injection same volume normal saline twice daily. Results Compared with MG, area cerebral infarction, pathological changes, neuron index, neurodeficit score significantly reduced (P < 0.05). Morris water maze test showed that group, incubation period shortened number platform crossings increased Furthermore, protein mRNA expressions cleaved caspase-3, Bax, p-53, p38 mitogen-activated kinase (MAPK) hippocampus, whereas Bcl-2 Conclusions attenuated apoptosis, alleviated CD beneficial effect IBI may be mediated via inhibition MAPK signaling pathway caspase-3 cascade reaction.

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ژورنال

عنوان ژورنال: Archives of Medical Science

سال: 2021

ISSN: ['2657-7941']

DOI: https://doi.org/10.5114/aoms/132229