Efficacy, Mechanism and Antiviral Resistance of Neuraminidase Inhibitors and Adamantane against Avian Influenza
نویسندگان
چکیده
منابع مشابه
Influenza neuraminidase inhibitors: antiviral action and mechanisms of resistance
There are two major classes of antivirals available for the treatment and prevention of influenza, the M2 inhibitors and the neuraminidase inhibitors (NAIs). The M2 inhibitors are cheap, but they are only effective against influenza A viruses, and resistance arises rapidly. The current influenza A H3N2 and pandemic A(H1N1)pdm09 viruses are already resistant to the M2 inhibitors as are many H5N1...
متن کاملDesign and antiviral properties of influenza virus neuraminidase inhibitors
During the infection cycle of influenza virus, progeny virions bud from the plasma membrane of infected cells. At that point they are potentially immobilised because of interactions between the viral haemagglutinin and sialic acid which is found in glycoconjugates on the cell surface and on glycoproteins of the virus itself Neuraminidase inhibitors might therefore be expected to have an antivir...
متن کاملNeuraminidase inhibitors and their role in avian and pandemic influenza.
Continuing occurrences of human infections with avian influenza A (H5N1) viruses have ignited increasing fears that the next influenza pandemic is imminent. Fortunately, options for antiviral prophylaxis and treatment have been improved dramatically since the previous pandemics by the availability of neuraminidase inhibitors such as zanamivir and oseltamivir. However, although the prophylactic ...
متن کاملSusceptibilities of antiviral-resistant influenza viruses to novel neuraminidase inhibitors.
The susceptibilities of five zanamivir-resistant and six oseltamivir-resistant influenza viruses were assessed against four neuraminidase (NA) inhibitors, including peramivir and A-315675, by a fluorometric NA activity inhibition assay. The enzyme activity of a majority of the variants was effectively inhibited by either A-315675 or both peramivir and A-315675 (50% inhibitory concentration, <10...
متن کاملTitle: Mechanism-based Covalent Neuraminidase Inhibitors with Broad Spectrum Influenza Antiviral Activity
Influenza antiviral agents play important roles in modulating disease severity and in controlling pandemics while vaccines are prepared, but the development of resistance to agents like the commonly used neuraminidase inhibitor Tamiflu may limit their future utility. We report here a completely new class of specific, mechanism-based anti-influenza drugs that function via the formation of a high...
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ژورنال
عنوان ژورنال: Indonesian Bulletin of Animal and Veterinary Sciences
سال: 2019
ISSN: 2354-6832,0216-6461
DOI: 10.14334/wartazoa.v29i2.1951