Electropermeabilization does not correlate with plasma membrane lipid oxidation

Modeling the induction of lipid membrane electropermeabilization.

Experiments show significant effects of an electric field on lipid membrane, leading to a pore formation when a high intensity field is applied. The phenomenon of electroporation is preceded by the induction and expansion of defects, responsible for the pre-pore excitation. We examine the mechanism of the induction of the field-driven defects by Monte Carlo simulations. The study is based on th...

Enhanced Ovarian Folliclular Development by Metformin Does Not Correlate with Pregnancy Rate: A Randomized Trial

Membrane destabilizations supporting electropermeabilization.

The cell membrane can be permeabilized when subjected to calibrated short electric pulses. This membrane alteration can be reversible, leaving cell viability unaffected. This set of events is called Electropermeabilization. This is now used in clinical applications to introduce hydrophilic drugs into the cytoplasm. While an empirical control of the electrical parameters is obtained, our knowled...

Cell membrane electropermeabilization with arbitrary pulse waveforms.

xposure of a biological cell to an electric field can produce a variety of responses [1]-[6]. If the field strength exceeds a certain threshold value, this leads to a large transient increase in membrane conductivity and permeability for ions and molecules (electropermeabilization, often also named electroporation) or to fusion of adjacent cells (electrofusion) [5], [6]. Nowadays, these phenome...

Cellular membrane permeability of anthracyclines does not correlate with their delivery in a tissue-isolated tumor.

The clearance of anthracyclines from the vasculature was studied in perfused tissue-isolated tumors. Human tumor lines MCF-7, U87, and LS174T were implanted in the ovarian fat pad of immune-deficient mice and grown isolated from the surrounding tissue. The initial and continuous tissue uptakes of doxorubicin, daunorubicin, and idarubicin were measured. The clearance of these anthracyclines from...