Electrophysiological actions of calcium ionophores in rabbit sino-atrial (SA) node cells and canine Purkinje fibers
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چکیده
منابع مشابه
Electrophysiological characteristics of canine atrial plateau fibers.
Right atria from dog hearts were immersed in Tyrode's solution with the endocardial surface of the anterior wall exposed. Glass microelectrodes were used to impale fibers in diSerent anatomical areas of this preparation. Electrical characteristics of atrial plateau fibers located along the caval border of the crista terminalis were compared with those of regular atrial fibers from other sites. ...
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Disopyramide phosphate is a new antiarrhythmic drug that has been shown to possess significant antiarrhythmic effects in animals and man. In the present investigation, the effects of 2, 5, and 10 mug/ml of disopyramide phosphate were studied on the electrophysiological properties of canine Purkinje fibers and ventricular muscle superfused in vitro. Transmembrane action potentials were recorded ...
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The effects of calcium ionophores X-537A, A23187, and PR-47 on the action potential of canine cardiac Purkinje fibers were studied using standard microelectrode techniques. The ionophores hyperpolarize the membrane potential, eliminate the notch on the action potential plateau, decrease action potential duration, decrease plateau amplitude and duration, decrease spontaneous diastolic depolariza...
متن کاملElectrophysiological effects of diphenylhydantoin on canine purkinje fibers.
The effects of diphenylbydantoin (DPH) were studied on isolated, perfused Purkinje fibers over a range of concentrations from lCh to 10 M. The time course of repolarization of the transmembrane action potential shortened due to abbreviation of all phases of repolarization. The effective refractory period also shortened during exposure to DPH, but to a lesser extent than the action potential. As...
متن کاملElectrophysiological Effects of DiphenylhydantoSn on Canine Purkinje Fibers
The effects of diphenylbydantoin (DPH) were studied on isolated, perfused Purkinje fibers over a range of concentrations from lCh to 10 M. The time course of repolarization of the transmembrane action potential shortened due to abbreviation of all phases of repolarization. The effective refractory period also shortened during exposure to DPH, but to a lesser extent than the action potential. As...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1987
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)58108-2