Electrostatic interactions are important for chaperone–client interaction in vivo

Needs Assessment Competencies: Are They Important for Extension Educators?

The purpose of this study was to determine the importance of eleven professional competencies related to needs assessment and program development; a secondary purpose was to identify the best time these competencies should be learned. The study followed a survey research design, in which 441 randomly selected extension educators in the North Central Region of the United States responded to a qu...

Are Abnormal Yolk Sac Characteristics Important Factors in Abortion Rates?

Are hydrodynamic interactions important in the kinetics of hydrophobic collapse?

We study the kinetics of assembly of two plates of varying hydrophobicity, including cases where drying occurs and water strongly solvates the plate surfaces. The potential of mean force and molecular-scale hydrodynamics are computed from molecular dynamics simulations in explicit solvent as a function of particle separation. In agreement with our recent work on nanospheres [J. Phys. Chem. B 20...

Identification of two interaction sites in SecY that are important for the functional interaction with SecA.

The motor protein SecA drives the translocation of (pre-)proteins across the SecYEG channel in the bacterial cytoplasmic membrane by nucleotide-dependent cycles of conformational changes often referred to as membrane insertion/de-insertion. Despite structural data on SecA and an archaeal homolog of SecYEG, the identity of the sites of interaction between SecA and SecYEG are unknown. Here, we sh...

Electrostatic Interactions in Biomolecular Systems

Electrostatic interactions are of fundamental importance in determining the structure, dynamics, and function of biomolecules. In particular, they play a key role in protein folding and stability, pH-induced conformational changes, recognition of substrates by receptors, enzymatic catalysis, and in the formation of polysaccharide-based gels. However, due to their magnitude and long-range nature...