Electrostatic interactions at the five-fold axis alter heparin-binding phenotype and drive enterovirus A71 virulence in mice
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چکیده
منابع مشابه
Enterovirus A71 Proteins: Structure and Function
Enterovirus A71 (EV-A71) infection has grown to become a serious threat to global public health. It is one of the major causes of hand, foot, and mouth disease (HFMD) in infants and young children. EV-A71 can also infect the central nervous system (CNS) and induce diverse neurological complications, such as brainstem encephalitis, aseptic meningitis, and acute flaccid paralysis, or even death. ...
متن کاملSuramin interacts with the positively charged region surrounding the 5-fold axis of the EV-A71 capsid and inhibits multiple enterovirus A
Suramin was previously shown to bind to the EV-A71 capsid through its naphthalenetrisulfonic acid groups, thereby reducing virus-cell binding and inhibiting viral replication. Here, we identify VP1-145 as the critical amino acid that accounts for the differential sensitivity of EVA-71 viruses to suramin. A single Q or G to E substitution at VP1-145 results in an approximately 30-fold shift of I...
متن کاملEnterovirus EV-A71 Vaccine Licensure: What’s next?
Submit Manuscript | http://medcraveonline.com neurological complications and cardiopulmonary diseases in young children [1-5]. In the past two decades, coxsackievirus A16 (CV-A16) and enterovirus 71 (EV-A71) have been the predominant etiologic agents of herpangina (HA) and hand, foot and mouth disease (HFMD) epidemics [5-7]. Several other enterovirus serotypes frequently co-circulate with EV-A7...
متن کاملEnterovirus A71 Subgenotype B5, France, 2013
To the Editor: We report the detection of human enterovirus A71 (EV-A71) subgenotype B5 in France, 6 years after it was first detected in Europe. EV-A71 belongs to the Enterovirus A species (genus Enterovirus, family Picornaviridae) and is a major cause of hand, foot and mouth disease (HFMD), sometimes associated with severe neurologic complications (1). EV-A71 strains are classified in 6 genot...
متن کاملGenetic Diversity of Enterovirus A71, India
We have identified circulation of 3 genogroups of enterovirus (EV) A71 in India. A new genogroup (proposed designation G) was discovered during this study. We isolated genogroups D and G in wide geographic areas but detected subgenogroup C1 only in 1 focus in western India. A systematic nationwide search for EV-A71 is warranted.
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ژورنال
عنوان ژورنال: PLOS Pathogens
سال: 2019
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1007863