Elevated Apolipoprotein A1 and HDL Cholesterol Associated with Age-related Macular Degeneration: 2 Population Cohorts

Abstract Context To enable prevention and treatment of age-related macular degeneration (AMD), understanding risk factors for AMD is important. Objective We tested the hypotheses that elevated plasma apolipoprotein A1 high-density lipoprotein (HDL) cholesterol low levels low-density (LDL) are associated with increased AMD. Methods From Danish general population, we studied 106 703 16 032 individuals in Copenhagen General Population Study (CGPS) City Heart (CCHS) median follow-up 9 32 years, respectively. The main outcome measures were 1787 CGPS 206 CCHS. Results Higher concentrations HDL cholesterol, lower LDL higher CGPS. After multifactorial adjustment, highest versus lowest quartile had hazard ratios 1.40 (95% CI: 1.20-1.63) 1.22 (1.03-1.45). Corresponding 1.18 (1.02-1.37). Per 100 mg/dL A1, 1 mmol/L (39 mg/dL) HDL, mmol/L) 1.53(1.31-1.80), 1.19 (1.07-1.32), 1.05 (1.00-1.11), respectively, similar results across strata different factors. also Conclusion Elevated