Elevated synthesis of an axonally transported protein correlates with axon outgrowth in normal and injured pyramidal tracts

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Elevated synthesis of an axonally transported protein correlates with axon outgrowth in normal and injured pyramidal tracts.

Axons of the adult mammalian CNS typically fail to regenerate after injury. Among the hypotheses to account for this failure is the proposition that certain axonal proteins necessary for axon growth are expressed in much greater abundance in developing than in mature neurons, and that these proteins are not reinduced after injury to mature axons (Skene and Willard, 1981b). In the present experi...

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Association of an Axonally Transported Polypeptide

Polypeptide H (mol wt 195,000) is axonally transported in rabbit retinal ganglion cells at a velocity of 0.7-1 .1 mm/d, i.e ., in the most slowly moving of the five transport groups described in these neurons . To identify the organelle with which H is associated, we purified H, prepared antibodies directed against it, and adsorbed the antibodies onto Formvar-coated electron microscope grids . ...

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Axonally transported proteins associated with axon growth in rabbit central and peripheral nervous systems

In an effort to determine whether the "growth state" and the "mature state" of a neuron are differentiated by different programs of gene expression, we have compared the rapidly transported (group I) proteins in growing and nongrowing axons in rabbits. We observed two polypeptides (GAP-23 and GAP-43) which were of particular interest because of their apparent association with axon growth. GAP-4...

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ژورنال

عنوان ژورنال: The Journal of Neuroscience

سال: 1986

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.06-09-02563.1986