Embryonic Stem Cell Specific “Master” Replication Origins at the Heart of the Loss of Pluripotency
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چکیده
منابع مشابه
Embryonic Stem Cell Specific “Master” Replication Origins at the Heart of the Loss of Pluripotency
Epigenetic regulation of the replication program during mammalian cell differentiation remains poorly understood. We performed an integrative analysis of eleven genome-wide epigenetic profiles at 100 kb resolution of Mean Replication Timing (MRT) data in six human cell lines. Compared to the organization in four chromatin states shared by the five somatic cell lines, embryonic stem cell (ESC) l...
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Molecular Mechanisms of Embryonic Stem Cell Pluripotency
Embryonic stem (ES) cells isolated from the inner cell mass (ICM) of blastocysts possess the defining pluroptency: unlimited self-renewal and giving rise to all cells of the organ‐ ism[1, 2]. Thus, ES cells hold great promise for regenerative medicine to treat many dis‐ eases including heart failure, diabetes, Alzheimer’s and Parkinson’s disease by replacing the damaged cells with ES cell-deriv...
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ژورنال
عنوان ژورنال: PLOS Computational Biology
سال: 2015
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1003969