Emerging hallmark of gliomas microenvironment in evading immunity: a basic concept

Abstract Background Over the last decade, since clinical trials examining targeted therapeutics for gliomas have failed to demonstrate a meaningful increase in survival, emphasis has recently been switched toward innovative techniques modulating immune response against tumors and their microenvironments (TME). Cancerous cells eleven hallmarks which make it distinct from normal ones, among is evasion. Immune evasion glioblastoma helps evade various treatment modalities. Summary Glioblastoma’s TME composed of array cellular actors, ranging peripherally derived variety organ-resident specialized cell types. For example, blood–brain barrier (BBB) serves as selective between systemic circulation brain, effectively separates other tissues. It capable blocking around 98% molecules that transport different medications target tumor. Objectives The purpose this paper offer concise overview fundamental immunology how ‘clever’ avoid system despite discovery immunotherapy glioma. Conclusions Herein, we highlight complex interplay tumor, TME, nearby structures makes difficult grasp approach tumor itself. Numerous researchers found brain critical regulator glioma growth efficacy.