Enantioselective Intramolecular Hydroarylation of Alkenes via Directed C−H Bond Activation
نویسندگان
چکیده
منابع مشابه
Enantioselective intramolecular hydroarylation of alkenes via directed C-H bond activation.
Highly enantioselective catalytic intramolecular ortho-alkylation of aromatic imines containing alkenyl groups tethered at the meta position relative to the imine directing group has been achieved using [RhCl(coe)2]2 and chiral phosphoramidite ligands. Cyclization of substrates containing 1,1- and 1,2-disubstituted as well as trisubstituted alkenes were achieved with enantioselectivities >90% e...
متن کاملCatalytic, Enantioselective, Intramolecular Sulfenofunctionalization of Alkenes with Phenols
The catalytic, enantioselective, cyclization of phenols with electrophilic sulfenophthalimides onto isolated or conjugated alkenes affords 2,3-disubstituted benzopyrans and benzoxepins. The reaction is catalyzed by a BINAM-based phosphoramide Lewis base catalyst which assists in the highly enantioselective formation of a thiiranium ion intermediate. The influence of nucleophile electron density...
متن کاملCatalytic, Enantioselective, Intramolecular Sulfenoamination of Alkenes with Anilines
A method for the catalytic, enantioselective, intramolecular sulfenoamination of alkenes with aniline nucleophiles has been developed. The method employs a chiral, Lewis basic selenophosphoramide catalyst and a Brønsted acid co-catalyst to promote stereocontrolled C-N and C-S bond formation by activation of an achiral sulfenylating agent. Benzoannulated nitrogen-containing heterocycles such as ...
متن کاملIntramolecular carbonickelation of alkenes
The efficiency of the intramolecular carbonickelation of substituted allylic ethers and amines has been studied to evaluate the influence of the groups borne by the double bond on this cyclization. The results show that when this reaction takes place, it affords only the 5-exo-trig cyclization products, viz. dihydrobenzofurans or indoles. Depending on the tethered heteroatom (O or N), the outco...
متن کاملInsertion of an alkene into an ester: intramolecular oxyacylation reaction of alkenes through acyl C-O bond activation.
lation” could be an alternative to the aldol reaction. Atom economy and ester manipulation, however, are rarely compatible: esters usually fragment after reactions with nucleophiles, or decarbonylate when activated with transition metals. In the rare cases when the acyl C O bond is activated and decarbonylation is suppressed, the acyl metal alkoxide complexes can undergo additional transformati...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2008
ISSN: 0022-3263,1520-6904
DOI: 10.1021/jo801098z