Enantioselective Organocatalyzed <i>aza</i> ‐Michael Addition Reaction of 2‐Hydroxybenzophenone Imines to Nitroolefins under Batch and Flow Conditions

Herein, an asymmetric organocatalytic aza-Michael addition reaction of ketimines to nitroolefins is presented. The use 2-hydroxybenzophenone imine improves the enantioselective N-centered nucleophiles nitroalkenes by means intramolecular hydrogen bond formation at moiety. Moreover, versatility process demonstrated under both batch and flow conditions, showing synthesis a large variety nitroamine derivatives with excellent yields enantioselectivities. In addition, we applied this methodology formal VNI, drug-like scaffold for treatment Chagas disease.