Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis
نویسندگان
چکیده
منابع مشابه
Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis.
Toxoplasma gondii is a widely distributed protozoan pathogen that causes devastating ocular and central nervous system disease. We show that the endochin-like quinolone (ELQ) class of compounds contains extremely potent inhibitors of T. gondii growth in vitro and is effective against acute and latent toxoplasmosis in mice. We screened 50 ELQs against T. gondii and selected two lead compounds, E...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2012
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1208069109