Endogenous Alpha-Synuclein Protein Analysis from Human Brain Tissues Using Single-Molecule Pull-Down Assay
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چکیده
منابع مشابه
Endogenous α-SYN protein analysis on human brain tissues using single-molecule pull-down assay
Alpha-synuclein (α-SYN) is a central molecule in Parkinson’s disease pathogenesis. Despite several studies, the molecular nature of endogenous α-SYN especially in human brain samples is still not well understood due to the lack of reliable methods and the limited amount of bio-specimens. Here, we introduce α-SYN single-molecule pull-down (α-SYN SiMPull) assay combined with in vivo protein cross...
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ژورنال
عنوان ژورنال: Analytical Chemistry
سال: 2017
ISSN: 0003-2700,1520-6882
DOI: 10.1021/acs.analchem.7b04335