Endostatin inhibits hypertrophic scarring in a rabbit ear model
نویسندگان
چکیده
منابع مشابه
The effects of collagenase ointment on the prevention of hypertrophic scarring in a rabbit ear scarring model: a pilot study.
UNLABELLED Collagen synthesis and degradation are important in scar maturation. Collagenase has been used for debridement of wounds and treatment of Dupuytren's disease but its effects on scar prevention are unknown. OBJECTIVE The objective of this study was to determine the effect of collagenase ointment on hypertrophic scar prevention by using a rabbit ear-scarring model. METHODS F...
متن کاملLocal Application of Statins Significantly Reduced Hypertrophic Scarring in a Rabbit Ear Model
BACKGROUND We previously showed that intradermal injection of statins is a successful treatment for hypertrophic scarring. Topical application has many advantages over intradermal injection. In this study, we demonstrate the efficacy of topical statin treatment in reducing scar in our validated rabbit ear scar model. METHODS Twenty New Zealand White rabbits were divided into 2 study groups, w...
متن کاملEffect of Mederma on hypertrophic scarring in the rabbit ear model.
Currently accepted conservative treatments of hypertrophic scars are limited to steroid injections, radiation therapy, and silicone occlusive therapy. However, the use of Mederma for these problematic lesions has become quite prevalent in the clinical setting. Little scientific evidence exists to support the efficacy of this product in reducing hypertrophic scars. The aim of this study was to s...
متن کاملRecombinant nAG (a Salamander-Derived Protein) Decreases the Formation of Hypertrophic Scarring in the Rabbit Ear Model
nAG (newt-Anterrior Gradient) protein is the key mediator of regrowth of amputated limbs in salamanders. In a previous work in our lab, a new nAG gene (suitable for humans) was designed and cloned. The cloned vector was transfected into primary human fibroblasts. The expression of nAG in human primary fibroblasts was found to suppress collagen expression. The current study shows that local inje...
متن کاملRecombinant human endostatin reduces hypertrophic scar formation in rabbit ear model through down-regulation of VEGF and TIMP-1.
BACKGROUND Recombinant human endostatin (Endostar) has been widely used to suppress angiogenesis in carcinoma patients. Hypertrophic scar (HS) tissue, much like a carcinoma, is often associated with angiogenesis. However, there have been few studies conducted on the effects of Endostar on HS or its mechanism. OBJECTIVE This paper investigated the effects Endostar on the HS of rabbit ears and ...
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ژورنال
عنوان ژورنال: Journal of Zhejiang University SCIENCE B
سال: 2013
ISSN: 1673-1581,1862-1783
DOI: 10.1631/jzus.b1200077