Endothelial Adherens Junctions
نویسندگان
چکیده
منابع مشابه
Endothelial adherens junctions at a glance.
Adherens junctions have an important role in the control of vascular permeability. These structures are located at cell-to-cell contacts, mediate cell adhesion and transfer intracellular signals. Adhesion is mediated by cadherins, which interact homophilically in trans and form lateral interactions in cis. VE-cadherin (also known as CDH5 and CD144) is the major component of endothelial adherens...
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Vascular endothelial cadherin (VE-cadherin) connects neighboring endothelial cells (ECs) via interendothelial junctions and regulates EC proliferation and adhesion during vasculogenesis and angiogenesis. The cytoplasmic domain of VE-cadherin recruits alpha- and beta-catenins and gamma-catenin, which interact with the actin cytoskeleton, thus modulating cell morphology. Dysregulation of the adhe...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology Symposium Proceedings
سال: 2000
ISSN: 1087-0024
DOI: 10.1046/j.1087-0024.2000.00002.x