Endothelial Damage and Repair in Myocardial ischemia and Reperfusion
نویسندگان
چکیده
منابع مشابه
Role of Endothelial Cells in Myocardial Ischemia-Reperfusion Injury
Minimizing myocardial ischemia-reperfusion injury has broad clinical implications and is a critical mediator of cardiac surgical outcomes. "Ischemic injury" results from a restriction in blood supply leading to a mismatch between oxygen supply and demand of a sufficient intensity and/or duration that leads to cell necrosis, whereas ischemia-reperfusion injury occurs when blood supply is restore...
متن کاملTime course of endothelial dysfunction and myocardial injury during myocardial ischemia and reperfusion in the cat.
Myocardial ischemia and reperfusion have been shown to impair coronary vasorelaxation to endothelium-dependent vasodilators. To examine the time course of this dysfunction, occlusion of the left anterior descending (LAD) coronary artery (90 minutes) was followed by reperfusion for 0, 2.5, 5, 20, 180, or 270 minutes. Coronary arterial rings from the ischemic LAD and control left circumflex (LCx)...
متن کاملIschemia-reperfusion damage.
Ischemia-reperfusion damage is a complex pathological process that begins with tissue anoxia and continues with the production of free oxygen radicals, expanding with the inflammatory response. The literature suggests the importance of antioxidant and anti-inflammatory treatment to treat ischemia-reperfusion-related tissue damage.
متن کاملThe Protective Effect of Antioxidant and Anti-inflammatory Nanoparticles in Renal Ischemia-Reperfusion Damage
Background& objectives: Renal ischemia-reperfusion (IR) damage occurs during renal transplantation in end-stage renal disease (ESRD) patients which activate immune responses. Inflammatory responses by increased levels of cytokines can lead to acute kidney injury (AKI) that contributes to the loss of renal grafts and graft dysfunction. The purpose of this study was to review the therapeutic effe...
متن کاملNew insights on myocardial pyridine nucleotides and thiol redox state in ischemia and reperfusion damage.
OBJECTIVE to investigate the changes of pyridine nucleotides and thiol redox state in cardiac tissue following ischemia and reperfusion. NADH/NAD and NADPH/NADP redox couples were specifically studied and the influence of NADPH availability on cellular thiol redox was also investigated. METHODS isolated rabbit hearts were Langendorff perfused and subjected to a protocol of ischemia and reperf...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Circulation Journal
سال: 1993
ISSN: 0047-1828,1347-4839
DOI: 10.1253/jcj.57.supplementiv_1186