Endowment of pH Responsivity to Anticancer Peptides by Introducing 2,3‐Diaminopropionic Acid Residues
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چکیده
منابع مشابه
In silico prediction of anticancer peptides by TRAINER tool
Cancer is one of the causes of death in the world. Several treatment methods exist against cancer cells such as radiotherapy and chemotherapy. Since traditional methods have side effects on normal cells and are expensive, identification and developing a new method to cancer therapy is very important. Antimicrobial peptides, present in a wide variety of organisms, such as plants, amphibians and ...
متن کاملin silico prediction of anticancer peptides by trainer tool
cancer is one of the causes of death in the world. several treatment methods exist against cancer cells such as radiotherapy and chemotherapy. since traditional methods have side effects on normal cells and are expensive, identification and developing a new method to cancer therapy is very important. antimicrobial peptides, present in a wide variety of organisms, such as plants, amphibians and ...
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23 Protein engineering is commonly used to improve the robustness of enzymes for 24 activity and stability at high temperatures. In this study, we identified four residues 25 expected to affect the thermostability of Streptomyces sp. S9 xylanase XynAS9 26 through multiple sequence analysis (MSA) and molecular dynamic simulations 27 (MDS). Site-directed mutagenesis was employed to construct five...
متن کاملD-amino acid residues in peptides and proteins.
We have investigated the D-amino acid residues present in Protein Data Bank (PDB) entries, categorizing them into "real" D-residues and artifacts. In polypeptide chains of more than 20 residues, only a single instance of a "real" D-residue, other than those deliberately designed or engineered, was found. This example was the result of a slow chemical epimerization process. Another 12 designed D...
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Antimicrobial peptides (AMPs) are part of the innate immune defense mechanism of many organisms. Although AMPs have been essentially studied and developed as potential alternatives for fighting infectious diseases, their use as anticancer peptides (ACPs) in cancer therapy either alone or in combination with other conventional drugs has been regarded as a therapeutic strategy to explore. As huma...
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ژورنال
عنوان ژورنال: ChemBioChem
سال: 2019
ISSN: 1439-4227,1439-7633
DOI: 10.1002/cbic.201900226