Engineered Tools to Study Intercellular Communication
نویسندگان
چکیده
منابع مشابه
Intercellular Communication in Bacteria
Historically, conventional thinking in evolutionary biology has drawn a bright line separating multicellular from unicellular organisms. Only the cells of animals, plants, and fungi were thought capable of achieving the synchrony required to function as a collective. Bacteria, in contrast, were perceived as blind, deaf, and mute, with each cell single-mindedly focusing on its own metabolism and...
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Cell-to-cell communication is a process necessary for physiological tissue homeostasis and appears often altered during disease. Gap junction channels, formed by connexins, allow the direct intercellular communication between adjacent cells. After a brief review of the pathophysiology of atherosclerosis, we will discuss the role of connexins throughout the different stages of the disease.
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Multicellular organisms depend on cell-to-cell communication to coordinate both development and environmental responses across diverse cell types. Intercellular signaling is particularly critical in plants because development is primarily postembryonic and continuous over a plant's life span. Additionally, development is impacted by restrictions imposed by a sessile lifestyle and limitations on...
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Bacteria are known to communicate primarily via secreted extracellular factors. Here we identify a previously uncharacterized type of bacterial communication mediated by nanotubes that bridge neighboring cells. Using Bacillus subtilis as a model organism, we visualized transfer of cytoplasmic fluorescent molecules between adjacent cells. Additionally, by coculturing strains harboring different ...
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Cross-talk between different cell types plays central roles both in cardiac homeostasis and in adaptive responses of the heart to stress. Cardiomyocytes (CMs) send biological messages to the other cell types present in the heart including endothelial cells (ECs) and fibroblasts. In turn, CMs receive messages from these cells. Recent evidence has now established that exosomes, nanosized secreted...
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ژورنال
عنوان ژورنال: Advanced Science
سال: 2020
ISSN: 2198-3844,2198-3844
DOI: 10.1002/advs.202002825